MCP Radar
MCP Server

nullary

ai.nullary/nullary
Healthcare Science & Engineering Public & reachable MCP 2025-11-25

What this MCP does

Provides access to measured negative results and failures relevant to drug discovery research.

Capabilities

Tools

35 tools
get_compound
A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'chembl_id': {'type': 'string', 'description': 'ChEMBL molecule ID, e.g. CHEMBL941.'}, 'inchi_key': {'type': 'string', 'description': 'Compound InChIKey (provide one of inchi_key, chembl_id, or pubchem_cid).'}, 'pubchem_cid': {'type': 'integer', 'description': 'PubChem Compound ID (CID).'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'compound': {'type': 'object', 'description': 'Identity: pref_name, chembl_id, inchi_key, max_phase.'}, 'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Every negative finding for this molecule.'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}, 'returned_count': {'type': 'integer'}}, 'description': "A compound's identity plus its full negative profile across modalities and sources."}
get_coverage
Per-modality and per-source coverage stats (honest Phase-1 numbers).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'properties': {}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'total': {'type': 'integer'}, 'by_modality': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Per-modality finding counts.'}, 'curated_total': {'type': 'integer'}, 'by_source_type': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Per-source finding counts.'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'Per-modality and per-source coverage counts.'}
get_finding_provenance
Full provenance + detail for a single finding by id.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['id'], 'properties': {'id': {'type': 'string', 'description': 'finding UUID'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'finding': {'type': 'object', 'description': 'The finding with source, DOI/PMID, assay context, and confidence tier.'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'A single finding with full provenance.'}
get_model_card
Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['target'], 'properties': {'target': {'type': 'string', 'description': 'gene symbol or UniProt accession (required)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'Per-target Layer-1 model card: training counts and held-out scaffold-split metrics.'}
get_target_landscape
Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['target'], 'properties': {'target': {'type': 'string', 'description': 'gene symbol or UniProt accession (required)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'summary': {'type': 'string', 'description': 'One-line natural-language summary.'}, 'by_outcome': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Per-outcome counts.'}, 'by_modality': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Per-modality failed-agent counts.'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'Target exhaustion index â\x80\x94 distinct agents tried-and-failed, by modality and outcome.'}
list_models
Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'properties': {}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'Summary of the Layer-1 model registry: counts by family and median scaffold-split ROC-AUC.'}
list_top_targets
Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'properties': {'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'family': {'type': 'string', 'description': 'target family filter (optional)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query.'}}, 'description': 'The most heavily-pursued targets, ranked by recorded negative findings.'}
search_adc_linker_failures
ADC failures attributed to linker chemistry.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_admet_failures
Small-molecule ADMET failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_admet_failures_all_modalities
ADMET failures across ALL modalities.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_ancestry_specific_failures
Ancestry-specific CRISPR failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_bispecific_format_failures
Bispecific format/engineering failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_developability_failures
Antibody developability failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_drug_drug_interaction_failures
Drug-drug interaction failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_adcs
ADCs that failed at any stage.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_bispecifics
Bispecifics that failed at any stage.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_clinical_antibodies
Discontinued/terminated clinical antibodies.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_essentiality_screens
Non-dependency / failed essentiality screens.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_guides
Failed/ineffective CRISPR guides.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_oligonucleotides
ASOs/siRNAs that failed engagement/developability.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_peptide_therapeutics
Failed peptide therapeutics.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_protacs
PROTACs that failed degradation/ternary/permeability.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_replications
Findings that failed to replicate.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_selectivity
Small molecules that failed selectivity.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_failed_vaccines
Failed/terminated vaccines (by pathogen/indication).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'indication': {'type': 'string', 'description': 'disease/indication'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_inactive_compounds
Inactive small-molecule compound-target pairs.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_indication_history
ALL failed approaches for an indication across every modality.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['indication'], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'indication': {'type': 'string', 'description': 'indication (required)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_mechanism_failures
Approaches that failed for a mechanism (by target).
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_oligo_delivery_failures
Oligonucleotide delivery failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_pathogen_history
Vaccine + antimicrobial + antibody failures for a pathogen.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['pathogen'], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'pathogen': {'type': 'string', 'description': 'pathogen name (required)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_peptide_stability_issues
Peptide stability/half-life failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_protac_e3_issues
PROTAC E3-ligase recruitment / ternary failures.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_safety_failures
Clinical/preclinical safety failures across modalities.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_target_history
ALL failed approaches against a target across every modality.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': ['target'], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol (required)'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
search_vaccine_immunogenicity_failures
Failed vaccine immunogen designs.
Read only Open world Idempotent
Input schema 
{'type': 'object', 'required': [], 'properties': {'tier': {'enum': ['curated', 'all'], 'type': 'string', 'default': 'curated', 'description': "Confidence tier. 'curated' (default) returns the credible layer; 'all' also includes high-volume screening-grade rows (PubChem HTS inactives, CRISPR non-essential tails)."}, 'limit': {'type': 'integer', 'default': 25, 'maximum': 100, 'minimum': 1, 'description': 'Maximum number of findings to return (1â\x80\x93100, default 25).'}, 'offset': {'type': 'integer', 'default': 0, 'minimum': 0, 'description': 'Number of findings to skip before this page, for pagination (default 0).'}, 'target': {'type': 'string', 'description': 'UniProt accession or gene symbol'}, 'outcome': {'type': 'string', 'description': 'outcome filter (inactive, failed_safety, terminated, â\x80¦)'}, 'compound': {'type': 'string', 'description': 'compound name, ChEMBL ID, or InChIKey'}}}
Output schema 
{'type': 'object', 'required': ['query_metadata'], 'properties': {'findings': {'type': 'array', 'items': {'type': 'object'}, 'description': 'Matching negative findings (same shape as the REST /findings endpoint).'}, 'has_more': {'type': 'boolean', 'description': 'True when more results exist beyond this page.'}, 'coverage_note': {'type': 'string', 'description': 'Honest coverage caveat for thin Phase-1 modalities (present only when relevant).'}, 'query_metadata': {'type': 'object', 'description': 'Echo of the resolved query â\x80\x94 tool, limit, offset, and any applied presets.'}, 'returned_count': {'type': 'integer', 'description': 'Findings returned in this page.'}}}
History

Recent tool changes

Added
get_coverage
Sept. 17, 2026, 7:57 a.m.
Added
get_model_card
Sept. 17, 2026, 7:57 a.m.
Added
list_models
Sept. 17, 2026, 7:57 a.m.
Added
list_top_targets
Sept. 17, 2026, 7:57 a.m.
Added
get_target_landscape
Sept. 17, 2026, 7:57 a.m.
Added
get_finding_provenance
Sept. 17, 2026, 7:57 a.m.
Added
get_compound
Sept. 17, 2026, 7:57 a.m.
Added
search_pathogen_history
Sept. 17, 2026, 7:57 a.m.
Added
search_indication_history
Sept. 17, 2026, 7:57 a.m.
Added
search_target_history
Sept. 17, 2026, 7:57 a.m.
Added
search_safety_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_replications
Sept. 17, 2026, 7:57 a.m.
Added
search_mechanism_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_drug_drug_interaction_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_admet_failures_all_modalities
Sept. 17, 2026, 7:57 a.m.
Added
search_bispecific_format_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_bispecifics
Sept. 17, 2026, 7:57 a.m.
Added
search_adc_linker_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_adcs
Sept. 17, 2026, 7:57 a.m.
Added
search_vaccine_immunogenicity_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_vaccines
Sept. 17, 2026, 7:57 a.m.
Added
search_oligo_delivery_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_oligonucleotides
Sept. 17, 2026, 7:57 a.m.
Added
search_protac_e3_issues
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_protacs
Sept. 17, 2026, 7:57 a.m.
Added
search_peptide_stability_issues
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_peptide_therapeutics
Sept. 17, 2026, 7:57 a.m.
Added
search_failed_clinical_antibodies
Sept. 17, 2026, 7:57 a.m.
Added
search_developability_failures
Sept. 17, 2026, 7:57 a.m.
Added
search_ancestry_specific_failures
Sept. 17, 2026, 7:57 a.m.
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Opentargets

io.github.pipeworx-io/opentargets

Provides Open Targets disease, drug, target, therapeutic-area, and disease-association knowledge graph lookups.

Chembl

io.github.pipeworx-io/chembl

Queries the ChEMBL drug-discovery database for molecules, mechanisms of action, indications, targets, and small-molecule bioactiv…

Hpo Api

io.github.pipeworx-io/hpo-api

Looks up Human Phenotype Ontology terms and associations between diseases, clinical phenotypes, and genes.